« The Red Pill » shifts from Cassie JAYE’s investigation of what she initially believed to be a hate movement to more sympathetic coverage of the movement. The shift is shown in the film through Jaye’s questions about her own views on gender, power, and privilege. « The Red Pill » also discusses issues facing men and boys. It includes interviews with men’s rights activists and those supportive of the movement, such as Paul Elam, founder of A Voice for Men; Harry CROUCH, president of the National Coalition for Men; Warren FARRELL, author of The Myth of Male Power; and Erin PIZZEY, who started the first domestic violence shelter in the modern world. It also includes interviews with feminists critical of the movement, such as Ms. magazine executive editor Katherine SPILLAR, and sociologist Michael KIMMEL. It also contains excerpts from JAYE’s video diary.

Some of the issues discussed as facing men and boys are male suicide rates, workplace fatalities and high-risk jobs, military conscription, lack of services for male victims of domestic violence and rape, higher rates of violent victimization, issues concerning divorce and child custody, disparity in criminal sentencing, disproportionately less funding and research on men’s health issues, educational inequality, societal tolerance of misandry, male genital mutilation, men’s lack of reproductive rights, life expectancy, false rape allegations, paternity fraud and homelessness.